Fly Tyrosine Kinase & PTP lists
Dept. of Biological Sciences
Illinois State University
Campus Box 4120
Normal IL 61790
email: kaedwar(at)ilstu.edu
Office: (309) 438-7689
| Ph.D. | Cell Biology | Duke University | 1996 |
|---|---|---|---|
| M.S. | Molecular Biology | San Diego State University | 1990 |
| B.S. | Biology (Genetics) | Oregon State University | 1986 |
| Aug. 2005 - present | Associate Professor of Genetics, Dept. of Biological Sciences, Illinois State University. |
| Aug. 1999 - Aug. 2005 | Assistant Professor of Genetics, Dept. of Biological Sciences, Illinois State University. |
| May 1996 - Aug. 1999 | Postdoctoral Researcher with Yamamoto Behavior Genes Project at Hawaii, Center for Conservation Research and Training, University of Hawaii, Manoa. Genomic and morphological evolution in genus Drosophila; genetic analysis of novel signaling/cytoskeletal proteins. |
| Aug. 1992 - Apr. 1996 | Ph.D. Student (advisor: Dr. D. P. Kiehart), Dept. of Cell Biology, Duke University Medical Center, Durham, NC. Characterization of cytoskeletal proteins using molecular, genetic, and cell biological techniques. Doctoral Thesis: Genetic analysis of myosin II and other cell shape determinants in Drosophila. |
| May - Aug. 1993 | Intern with Dr. P. Sherman, Div. of Experimental Therapy, Burroughs-Wellcome, Research Triangle Park, NC. |
| Apr. 1990 - Jul. 1992 | Research Associate with Dr. Kiehart, Dept. of Cell & Developmental Biology, Harvard University, Cambridge, MA. |
| Feb. 1988 - Mar. 1990 | Masters Student (advisor: Dr. S. I. Bernstein), Molecular Biology Institute, San Diego State University, San Diego, CA. Master's Degree Thesis: Stage, tissue, and cell type specific alternative splicing of myosin heavy chain mRNAs in Drosophila. |
| Dates | Agency/ Program | Project Title | PIs |
|---|---|---|---|
| 2007-2009 | NIH/NIGMS (R15) GM62185 (renewal) | Functions of Drosophila Phosphatases Pez and Meg | K. Edwards, PI |
| 2006-2008 | NSF Major Research Instrumentation | Acquisition of a Sequencing and Microarray Facility for Illinois State University | C. Gatto, Lead PI; K. Edwards, Co-PI |
| 2005-2007 | NIH/NIEHS (R03) ES013516 | Genetic inactivation of the Drosophila P450 system | K. Edwards, PI |
| 2004-2007 | NSF -Div. of Biol. Infrastructure, DBI0400675 | A confocal microscope for 4dimensional biological imaging | K. Edwards, Lead PI; D. Borst, R. Preston, Co-PIs |
Genetics Society of America, American Society for Cell Biology, American Association for the Advancement of Science
Edwards, K.A., L.T. Doescher, K.Y. Kaneshiro, and D. Yamamoto. 2007. A database of wing diversity in the Hawaiian Drosophila. PLoS ONE 2(5): e487, 1-12. doi:10.1371/journal.pone.0000487
Wang, H., S. Singh, Z. Zheng, S. Oh, X. Chen, K. Edwards, and S. X. Hou. 2006. Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-Cadherin-mediated cell adhesion in the Drosophila testis. Developmental Cell 10:117-126.
Park, H.*, and K. Edwards. 2004. "Marker removal" screen to generate an improved wing disc GAL4 driver. Drosophila Information Service 87:96-99. [*Undergraduate researcher]
Holford, K.C., K.A. Edwards, W.G. Bendena, S.S. Tobe, Z. Wang, and D.W. Borst. 2004. Purification and characterization of a mandibular organ protein from the American lobster, Homarus americanus: a putative farnesoic acid O-methyltransferase. Insect Biochem. Molec. Biol. 34:785-798
Bretscher, A., K. Edwards, and R.G. Fehon. 2002. ERM proteins and merlin: integrators at the cell cortex. Nature Reviews Molecular Cell Biol. 3:586-599. [Review]
Edwards, K.A., T. Davis, D. Marcey, J. Kurihara, and D. Yamamoto. 2001. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Gene 275:195-205.
Champagne, M.B., K.A. Edwards, H.P. Erickson, and D.P. Kiehart. 2000. Drosophila Stretchin-MLCK is a novel member of the Titin/Myosin Light Chain Kinase family. J. Mol. Biol. 300:1279-1297.
Kambysellis, M., E. Craddock, S. Montgomery, K. Kaneshiro, K. Edwards, and H. Carson. 2000. Ecology and evolution of Drosophila ambochila, a rare picture-winged species endemic to the Waianae Range of Oahu, Hawaiian Islands. Pacific Science 54:169-181.
Kiehart, D.P., C.G. Galbraith, K.A. Edwards, W.L. Rickoll, and R.A. Montague. 2000. Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. J. Cell Biol. 149:471-490.
True, J.R., K.A. Edwards, D. Yamamoto, and S.B. Carroll. 1999. Drosophila wing melanin patterns form by vein-dependent elaboration of enzymatic prepatterns. Current Biology 9:1382-1391. [See Dispatch by O'Grady and DeSalle (2000) Current Biology 10:R75-R77.]
Li, M.-g., M. Serr, K. Edwards, S. Ludmann, D. Yamamoto, L. Tilney, C. Field, and T. Hays. 1999. Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis. J. Cell Biol. 146:1061-1074.
Edwards, K.A., M. Demsky, R.A. Montague, N. Weymouth and D.P. Kiehart. 1997. GFP-Moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. Developmental Biology 191:103-117.
Edwards, K.A. and D.P. Kiehart. 1996. Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis. Development 122:1499-1511.
Wells, L., K.A. Edwards, and S.I. Bernstein. 1996. Myosin heavy chain isoforms regulate muscle function but not myofibril assembly. EMBO J. 15:4454-4459.
Zhang, X., V.E. Laubach, E.W. Alley, K.A. Edwards, P.A. Sherman, S.W. Russell, and W.J. Murphy. 1996. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma. J. Leukocyte Biol. 59:575-585.
Edwards, K.A., X.-j. Chang, and D.P. Kiehart. 1995. Essential light chain of Drosophila nonmuscle myosin II. J. Muscle Research & Cell Motility 16:491-498.
Edwards, K.A., R.A. Montague, S. Shepard, B.A. Edgar, R.L. Erikson and D.P. Kiehart. 1994. Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. Proc. Nat. Acad. Sci. USA 91:489-493.
Kronert, W.A., K.A. Edwards, E.S. Roche, L. Wells, and S.I. Bernstein. 1991. Muscle-specific accumulation of Drosophila myosin heavy chains: a splicing mutation in an alternative exon results in an isoform substitution. EMBO J. 10:2479-2488.
Karess, R.E., X.-j. Chang, K.A. Edwards, S. Kulkarni, I. Aguilera, and D.P. Kiehart. 1991. The regulatory light chain of nonmuscle myosin is encoded by spaghetti squash, a gene required for cytokinesis in Drosophila. Cell 65:1177-1189.
Collier, V.L., W.A. Kronert, P.T. O'Donnell, K.A. Edwards, and S.I. Bernstein. 1990. Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed. Genes & Development 4:885-895.
Larson T., K. Vadali, and K. Edwards. 2007. FERM domain specifies apical localization of protein tyrosine phosphatase Pez. 48th Ann. Drosophila Research Conference.
Edwards, K., E. Murray, D. Whitman, and K. Vadali. 2006. Large scale cytoskeletal structures support grasshopper oogenesis. American Soc. for Cell Biol. 45th Ann. Meeting.
Marada, S., W. Mulugeta, C. Weddle, S. Gavin, and K. Edwards. 2006. Drosophila Cytochrome P450 Reductase (CPR) is essential for development and offers a model for Antley-Bixler Syndrome. 47th Ann. Drosophila Research Conference.
Vadali, K., S. Galewsky, W. Mulugeta, C. Gatto, H. Park, and K. Edwards. 2006. Tyrosine phosphatase Pez antagonizes actin but not RTK signaling. 47th Ann. Drosophila Research Conference.
Marada, S., W. Mulugeta, A. Verma, C. Weddle, S. Gavin, and K. Edwards. 2005. Genetic analysis of Cytochrome P450 Reductase in Drosophila melanogaster. 14th International Conference on Cytochromes P450 (ASBMB Symposium).
Singh, S.R., S. Oh, Z. Zheng, X. Chen, K. Edwards, and S.X. Hou. 2005. Mutation of a small GTPase-GEF results in the supernumerary spermathecae formation of the females of Drosophilamelanogaster. 46th Ann. Drosophila Research Conference.
Vadali, K., A. Saraiva, M. Vepakomma, C. Weddle, C. Gatto, and K. Edwards. 2004. Novel assays for protein tyrosine phosphatase activity in vivo and in vitro. 45th Ann. Drosophila Research Conference.
Edwards, K., K. Vadali, S. Duellman, and D.J. Marcey. 2003. Is Extra eye a tyrosine phosphatase? 44th Ann. Drosophila Research Conference.
Edwards, K., M. Vepakomma, W. Mulugeta, R. Bradshaw, and D. Yamamoto. 2002. Genetic and biochemical analysis of Pez and Meg, two novel protein tyrosine phosphatases. 43rd Ann. Drosophila Research Conference.
Bottalico, A., M. Garcia, K. Edwards, S. Kunes, and Q. He. 2002. A role for gene dizzy in the visual system development of Drosophila melanogaster. 43rd Ann. Drosophila Research Conference.
Edwards, K. 2001. Evolution of the FERM domain, a protein interaction module found in cytoskeletal proteins, tumor suppressors, and tyrosine phosphatases. 42nd Ann. Drosophila Research Conference.
Edwards, K., T. Davis, and D. Yamamoto. 2000. Fly FERM-PTPs: evolution of a class of tyrosine phosphatases related to cytoskeletal proteins and tumor suppressors. FASEB Summer Research Conference on Protein Phosphatases.
Edwards, K., J. Kurihara, E. Yoshino, and D. Yamamoto. 2000. Complex distribution of breakpoints following P element imprecise excision in the presence of a homologue. 41st Ann. Drosophila Research Conference.
Edwards, K., K. Kaneshiro, and D. Yamamoto. 1999. Rhophilin, a putative effector for the cytoskeletal regulator rho, is not essential for development. 40th Ann. Drosophila Research Conference.
Kambysellis, M., E. Craddock, S. Montgomery, K. Kaneshiro, and K. Edwards. 1999. Ovipositional resource partitioning: A key factor in the Hawaiian Drosophila radiation. 40th Ann. Drosophila Research Conference.
Edwards, K., K. Kaneshiro, and D. Yamamoto. 1998. Drosophila Rhophilin contains a PDZ domain similar to those of RGS/rhoGEF proteins. (American Soc. for Cell Biol. 38th Ann. Meeting.) Molec. Biol. of the Cell 9S:284a.
Alcorta, D., R.A. Montague, K. Edwards, and D.P. Kiehart. 1998. GFP-Moesin fusion proteins function as real-time markers of actin cable reorganization in cultured cells. (American Soc. for Cell Biol. 38th Ann. Meeting.) Molec. Biol. of the Cell 9S:142a.
Davis, T., K. Edwards, L. Doescher, J. Kurihara, A. Lacre, Y. Nakano, H. Carson, K. Kaneshiro, and D. Yamamoto. 1998. Physical mapping of Hawaiian Drosophila chromosomes using homologues of Drosophila melanogaster genes. 39th Ann. Drosophila Research Conference.
Edwards, K., Y. Nakano, K. Majima, J. Kurihara, K. Kaneshiro, D. Yamamoto. 1997. DNA sequence analyses reveal a new phylogeny of Hawaiian Drosophilidae and over 20 novel Drosophila genes. (Slide talk.) 38th Ann. Drosophila Research Conference.
