Phylogenetic tree demonstrates orthology relationships within the FERM domain superfamily. In nearly all cases, groups of FERM domains which cluster together have very similar tails (see icons). Sequences are derived from three species: human (H., not highlighted), D. melanogaster (D., highlighted yellow) and C. elegans (C., highlighted pink). For NBL4 only, the mouse sequence was used since the human protein was known only from rough EST sequence. The unrooted tree was constructed using web-based versions of CLUSTALW and DRAWTREE (http://workbench.sdsc.edu), from a manual alignment of 42 superfamily members in the region corresponding to the crystallized portion of human moesin (residues 1-297). Bootstrap values obtained from the CLUSTALTREE program are indicated at each node (except nodes in the ERM subfamily). The JAK/FAK/KIAA0316 portion of the superfamily was omitted from the alignment due to its extremely low sequence similarity to the proteins shown, but its placement is indicated (dotted lines) based on a similar tree by Girault et al. (1999; Molec. Med. 4:755).

This work was published in Bretscher et al. 2002.