Education:
B.S. in Biology, Milligan
College, 1986.
Ph.D. in Genetics, The
University of Iowa, 1992.
Publications:
Jones, P.A., Samuels, N.M.,
Phillips, N.J., Munson, Jr., R.S., Bozue, J.A., Arseneau,
J.A., Nichols, W.A., Zaleski, A., Gibson, B.W. and Apicella,
M.A. (2002). Haemophilus inlfluenzae type b strain
A2 has multiple sialyltransferases involved in
lipooligosaccharide sialylation. Journal of Biological
Chemistry 277:14598-14611.
Swords, W.E., Buscher, B.A., Ver
Steeg II, K., Preston, A., Nichols, W.A., Weiser, J.N.,
Gibson, B.W., and Apicella, M.A. (2000). Non-typeable Haemophilus
influenzae adhere to and invade human bronchial
epithelial cells via an interaction of lipooligosaccharide
with PAF receptor. Molecular Microbiology 37:13-27.
Nichols, W.A., Gibson, B.W.,
Melaugh, W., Lee, N.-G., Sunshine, M. and Apicella, M.A.
(1997). Identification of the
ADP-L-glycero-D-manno-heptose-6-epimerase (rfaD) and
heptosyltransferase II (rfaF) biosynthesis genes from
nontypeable Haemophilus influenzae 2019. Infect.
Immun. 65:1377-1386.
Nichols, W.A., Raetz, C.R.H.,
Clementz, T., Smith, A.L., Hanson, J.A., Ketterer, M.R.,
Sunshine, M. and Apicella, M. A. (1997). HtrB of Haemophilus
influenzae: determination of biochemical activity and
effects on virulence and lipooligosaccharide toxicity. Journal
of Endotoxin Research 4:163-172.
Sunshine, M.G., Gibson, B.W.,
Engstrom, J.J., Nichols, W.A., Jones, B.D. and Apicella, M.A.
(1997). Mutation of the htrB gene in a virulent Salmonella
typhimurium strain by intergeneric transduction: strain
construction and phenotypic characterization. J. Bacteriol
179:5521-5533.
Jones, B.D., Nichols, W.A., Gibson,
B.W., Sunshine, M.G. and Apicella, M.A. (1997). Study of the
role of the htrB gene in Salmonella typhimurium
virulence. Infect. Immun.
DeMaria, T.F., Apicella, M.A.,
Nichols, W.A. and Leake, E.R. (1997). Evaluation of the
virulence of nontypeable Haemophilus influenzae
lipooligosaccharide htrB and rfaD mutants in
the chinchilla model of otitis media. Infect. Immun.
Current Grant support:
National Institutes of Health: NIAID
Links:
The Haemophilus influenzae
genomic sequence database at TIGR
The American Society for Microbiology
National Center for Biotechnology
Information
National Institutes of Health
Haemophilus influenzae
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